Aza-Macrocyclic Triphenylamine Ligands for G-Quadruplex Recognition
نویسندگان
چکیده
منابع مشابه
G-quadruplex recognition by macrocyclic hexaoxazole (6OTD) dimer.
Telomestatin (TMS: 1) is as a potent and selective telomeric G-quadruplex binder. Two molecules of TMS were suggested to be intercalated to one telomeric G-quadruplex according to docking study. In this paper, we designed and synthesized hexaoxazole TMS derivative (6OTD) dimer, and evaluated its G-quadruplex stabilizing ability.
متن کاملMacrocyclic and helical oligoamides as a new class of G-quadruplex ligands.
Ligands Pravin S. Shirude,† Elizabeth R. Gillies,‡ Sylvain Ladame,† Frédéric Godde,‡ Kazuo Shin-ya,§ Ivan Huc,*,‡ and Shankar Balasubramanian*,† UniVersity Chemical Laboratory, UniVersity of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K., Institut Européen de Chimie et Biologie, UniVersité Bordeaux 1-CNRS UMR 5248, 2 rue Robert Escarpit, 33607 Pessac, France, and Chemical Biology Team, Biol...
متن کاملG-quadruplex ligands exhibit differential G-tetrad selectivity.
A rapid and simple equilibrium-binding assay mediated by ligand-induced fluorescence quenching of fluorophore-labelled G-quadruplex (G4) structures enabled quantitative interrogation of mutually exclusive ligand binding interactions at opposed G-tetrads. This technique revealed that the ligands TmPyP4, PhenDC3, and PDS have differential chemotype-specific binding preferences for individual G-te...
متن کاملSmall-Molecule-Based Self-Assembled Ligands for G-Quadruplex DNA Surface Recognition
Most drugs are small molecules because of their attractive pharmacokinetics, manageable development and manufacturing, and effective binding into the concave crevices of bio-macromolecules. Despite these features, they often fall short when it comes to effectively recognizing the surfaces of bio-macromolecules. One way to overcome the challenge of biomolecular surface recognition is to develop ...
متن کاملA new method for the study of G-quadruplex ligands.
A new method for the study of G-quadruplex ligands was developed, in which the interaction of G-quadruplexes with ligands can be judged by the naked eye, eliminating the need for any expensive machines.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemistry - A European Journal
سال: 2018
ISSN: 0947-6539
DOI: 10.1002/chem.201802077